Short answer
CJC-1295 without DAC is a modified growth hormone releasing hormone analogue studied at the GHRH receptor. Ipamorelin is a pentapeptide studied at the ghrelin receptor, also called the growth hormone secretagogue receptor. Different receptor families, different half lives, and that separation is the stated rationale behind the combined blend.
CJC-1295 and Ipamorelin appear together so often that many buyers assume they are two names for one thing. They are separate molecules acting on separate receptor families, which is exactly why the blend exists. Here is the distinction as the literature describes it.
What is CJC-1295 without DAC?
CJC-1295 without DAC is a synthetic analogue of the first 29 amino acids of growth hormone releasing hormone, with substitutions intended to resist enzymatic breakdown. It is frequently written as modified GRF 1 to 29 in the literature.
It is studied at the GHRH receptor in preclinical endocrine models. The version carrying the drug affinity complex has a substantially longer described half life and should be treated as a separate compound.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide studied at the growth hormone secretagogue receptor, the same receptor family associated with ghrelin. Published work describes it as comparatively selective within that family.
Its sequence has no structural relationship to growth hormone releasing hormone, which is why it is not a substitute for CJC-1295 in a study design.
| Property | CJC-1295 no DAC | Ipamorelin |
|---|---|---|
| Peptide class | GHRH analogue, modified GRF 1 to 29 | Pentapeptide secretagogue |
| Receptor studied | GHRH receptor | Ghrelin receptor |
| Described half life | Short | Short |
| Sold as a blend | Yes, with Ipamorelin | Yes, with CJC-1295 |
| Laboratory handling | Lyophilised vial, reconstituted | Lyophilised vial, reconstituted |
How do they compare in practice?
- Receptor family: GHRH receptor for CJC-1295, ghrelin receptor for Ipamorelin.
- Described half life: short for the no DAC version, short for Ipamorelin, much longer for CJC-1295 with DAC.
- Formats stocked: CJC-1295 (no DAC) 10mg vial, Ipamorelin 10mg vial, and a prepared blend vial at 10mg.
- Handling: identical storage, reconstitution and documentation requirements.
Which one fits a given research model?
That depends on the receptor the model is built around. Work examining GHRH receptor signalling uses the analogue; work examining secretagogue receptor selectivity uses the pentapeptide; work comparing pathway interaction uses both, which is what the blend is prepared for.
None of this is guidance for use in humans. There are no approved human indications for either compound in the European Union.
Research use only
CJC-1295 and Ipamorelin are supplied by Vitality Peps for in vitro laboratory research only. Not for human or veterinary consumption.
Frequently asked questions
What is the difference between CJC-1295 and Ipamorelin?
The receptor they are studied at. CJC-1295 without DAC, also known as modified GRF 1 to 29, is a growth hormone releasing hormone analogue examined at the GHRH receptor. Ipamorelin is a pentapeptide examined at the ghrelin receptor. They are unrelated sequences.
Why are they sold as a blend?
Because the two receptor pathways are distinct, preclinical work has examined them in parallel rather than as substitutes. Vitality Peps supplies a prepared CJC-1295 and Ipamorelin blend vial for research that calls for both in fixed proportion, alongside the single compound vials.
What does no DAC mean?
DAC is a drug affinity complex added to some CJC-1295 preparations to extend circulating half life by binding albumin. The no DAC version omits it, so its published pharmacokinetic profile is much shorter. The two versions are not interchangeable in a study design.
Are they handled differently?
No. Both are supplied lyophilised, reconstituted with bacteriostatic water, kept refrigerated once in solution and protected from light. Concentration must be calculated from the vial mass on the label of the specific product.
For research purposes only. Not for human consumption. This article is educational and references published laboratory research; it is not medical advice and does not describe an approved use of any compound.